Friday, January 25, 2019

Tamiflu (oseltamivir) Dosing, Indications, Interactions, Adverse Effects





Tamiflu ( Oseltamivir)

Dosing & Uses

Dosage forms and powers

Capsule
•  
30mg
•  45mg
•  75mg
Powder for oral suspension
•  
6mg / ml

Influenza A and B Prophylaxis

•  75 mg PO qday for at least 10 days
Dosage ideas
•  
Start within 48 hours of Exposure
•  For community outbreaks, you can administer for 6 weeks

Influenza A and B Treatment

•  75 mg PO q12hr x5 day
Dosage Ideas
•  
Begin the influenza symptom within 48 hours of starting

H1N1 Influenza A (Swine Flu) Prophylaxis (Off-label)

75 mg PO qDay
Dosage Ideas
•  
Postexposure prophylaxis: Begin within 7 days of exposure and continue for at least 10 days
•  Preexposure prophylaxis: Start during the potential exposure period and continue after 10 days of the last known exposure.

H1N1 Influenza A (Swine Flu) Treatment (off-label)

75 mg PO q12hr x5 day
Dosage Ideas
•  
Begin the influenza symptom within 48 hours of starting

Dose modification

Renal impairment
Treatment
•  CRCL> 60 mL / min: no dose adjustment is necessary
•  CRCL> 30 to 60 mL / min: 30 mg PO bid
•  CRCL> 10 to 30 mL / min: 30 mg po qday
•  End-stage kidney disease (do not undergo dialysis): Not recommended (not studied)
Prophylaxis
•  CRCL> 60 mL / min: no dose adjustment is necessary
•  CRCL> 30 to 60 mL / min: 30 mg po qday
•  CRCL> 10 to 30 mL / min: 30 mg PO every other day
•  End-stage kidney disease (do not undergo dialysis): Not recommended (not studied)

Interections

Clopidogrel

Clopidogril reduces Tamiflu ( Oseltamivir) levels by others (see note). Use caution / monitor. Remarks: Clopidogrel can reduce serum concentrations of active metabolite (S) of Tamiflu ( Oseltamivir). .

Influenza virus vaccine quadrivalent

The influenza virus vaccine by Tamiflu ( Oseltamivir) pharmacodynamic rivalry reduces the effect of quadrivalent. Use caution / monitor. Avoid the administration of live-influenza influenza vaccine intravenous, within 2 weeks or 48 hours after the administration of Tamiflu ( Oseltamivir), unless prescribed for medical signs. Read More


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